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Despite the development of effective oral phosphodiesterase type 5 (PDE5) inhibitors for treatment of erectile dysfunction (ED), millions of men remain refractory to this class of drug. Clearly, novel molecular targets in the corpus cavernosum smooth muscle (CCSM) need to be identified and...
Duplex Doppler penile ultrasound (DDPU) is a useful, minimally invasive method for evaluating penile hemodynamics in patients with erectile dysfunction. The measurement of peak flow velocity, end-diastolic flow, and resistance index is helpful in assessment of the penile vascular status,...
Retrograde ejaculation (RE) is a well-known cause of male factor infertility. Recognized causes of RE include previous genitourinary surgery involving the bladder neck, genitourinary trauma, neurologic conditions, and side effects from medications. Diagnosis of RE is generally based on thorough...
Erectile dysfunction and hypogonadism are becoming two of the most frequently diagnosed sexual dysfunctions in men. They are often diagnosed together, and more men than before are being treated with both testosterone and phosphodiesterase type 5 inhibitors. Testosterone supplementation is a safe...
Injection therapy is the most effective pharmacotherapy for erectile dysfunction. Unfortunately, it has been all but forgotten by most practitioners since the advent of the oral therapy. Physicians rarely offer injection therapy as an option, despite the fact that over 6 million men have tried...
Prostate cancer is the most common noncutaneous malignancy in US men, with an estimated 232,000 new cases diagnosed in 2005. Radical prostatectomy (RP) has proved to be a safe and effective therapy for localized prostate cancer. However, RP can be associated with some risk of morbidity, which...
The advent of phosphodiesterase type 5 inhibitors (eg, sildenafil, vardenafil, tadalafil) as safe and effective forms of oral drug therapy for erectile dysfunction (ED) has lead to a larger number of patients seeking therapy for this medical condition. However, not all men receive an effective...
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