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Retinal proteins from halophilic archaea provide a unique opportunity to analyze vectorial ion translocation. Studies on its structure, conformational changes, proton conduction and electrogenic steps have helped to elucidate the catalytic cycle of bacteriorhodopsin in increasing detail....
Proton translocation is the means by which free energy is conserved from oxygen reduction by the respiratory heme-copper oxidases and from sunlight by bacteriorhodopsin. Three-dimensional structures at atomic resolution of both proteins have aided functional studies of the proton translocation...
Recent X-ray diffraction and Fourier transform IR spectroscopic studies have unveiled a great diversity in the molecular conformation and chain packing of lipid molecules containing cis -unsaturated fatty-acid chains. Specifically, a dramatic diversity in the olefinic conformation, subcell...
Electron cryocrystallography of precipitant-induced two-dimensional surface crystals of the neurospora plasma membrane H + -ATPase and tubular crystals of the sarcoplasmic reticulum Ca 2+ -ATPase has recently yielded structure maps for these ion transporters at a resolution of about 8 Å. The...
What is the connection among the following three medical conditions: Niemann-Pick type C disease (a cause of mental retardation and early death), systemic lipidosis (in which an obscure side effect of numerous drugs transforms lysosomes into lamellar bodies), and holoprosencephaly (a catastrophe...
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