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Many important cellular processes such as phagocytosis, cell motility and endocytosis require the participation of a dynamic and interactive actin cytoskeleton that acts to deform cellular membranes. The extensive family of non-traditional myosins has been implicated in linking the cortical actin...
Par6 and atypical protein kinase C are key players in the establishment of cell polarity. First discovered in Caenorhabditis elegans , the function of this protein complex is conserved in all multicellular organisms. Recent work is beginning to throw light on how it converts information generated...
Microtubule nucleation is the process in which several tubulin molecules interact to form a microtubule seed. Microtubule nucleation occurs spontaneously in purified tubulin solutions, and molecular intermediates between tubulin dimers and microtubules have been identified. Microtubule nucleation...