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Targeted metabolomics, aimed at the study of metabolic reaction networks and their regulation in vivo , is a rapidly emerging field in systems biology. Obtaining proper quantitative snapshots of the microbial metabolome requires fast sampling, immediate quenching of enzymatic activity, separation...
Analytical approaches for a comprehensive understanding of the metabolic networks in microbial cultures are mostly based on small-scale cultures which are in a steady state or undergo dynamic changes. For drawing conclusions to industrial-scale bioprocesses, however, it is important to understand...
Fluxes and metabolites are the functional manifestations of a living cell. Metabolic flux analysis evolved as a powerful means for systems biology to quantitatively analyze intracellular flux distributions. With the integration of data from tracer experiments, the formerly descriptive methodology...