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During translation, mRNA is threaded through the ribosome in precise and directional three-nucleotide steps. A recent paper identifies a new GTPase, LepA, which catalyzes unexpected one-codon backward movement on the ribosome.
Cytokinesis is regulated by both astral microtubules and the midzone microtubules of the mitotic apparatus. A new study in Caenorhabditis elegans has identified the polarity factor LET-99 and its heterotrimeric G-protein regulators as components of the signaling pathway downstream of astral...
This month's report from climate scientists firmed up fears about the potential problem and the likely extent of measures needed to tackle them. Nigel Williams reports.
Background Approximately one-third of the Drosophila kinome has been ascribed some cell-cycle function. However, little is known about which of its 117 protein phosphatases (PPs) or subunits have counteracting roles.
Background The mitotic kinases, Cdk1, Aurora A/B, and Polo-like kinase 1 (Plk1) have been characterized extensively to further understanding of mitotic mechanisms and as potential targets for cancer therapy. Cdk1 and Aurora kinase studies have been facilitated by small-molecule inhibitors, but...
Whether fundamental visual attributes, such as color, motion, and shape, are analyzed separately in specialized pathways has been one of the central questions of visual neuroscience (1–3) . Although recent studies have revealed various forms of cross-attribute interactions, including...
The localization of oskar mRNA to the posterior of the Drosophila oocyte defines the site of assembly of the pole plasm, which contains the abdominal and germline determinants (1–3) . oskar mRNA localization requires the polarization of the microtubule cytoskeleton, which depends on the...
The Mre11 complex (consisting of MRE11, RAD50, and NBS1/Xrs2) is required for double-strand break (DSB) formation, processing, and checkpoint signaling during meiotic cell division in S. cerevisiae (1–8) . Whereas studies of Mre11 complex mutants in S. pombe and A. thaliana indicate that the...
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