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Short interfering RNAs (siRNAs) guide mRNA cleavage during RNA interference (RNAi) (1–3) . Only one siRNA strand assembles into the RNA-induced silencing complex (RISC) (4) , with preference given to the strand whose 5′ terminus has lower base-pairing stability (5, 6) . In Drosophila ,...
In centrosome-containing cells, microtubules nucleated at centrosomes are thought to play a major role in spindle assembly (1) . In addition, microtubule formation at kinetochores has also been observed (2–5) , most recently under physiological conditions in live cells (6) . The relative...
Animals organize their lives around circannual and circadian rhythms, but little is known of their use of much shorter intervals (1) . In the laboratory, some animals can learn the specific duration (seconds or minutes) between periods of food access (2) . It has been supposed that wild...
APOBEC3 proteins constitute a family of cytidine deaminases that provide intracellular resistance to retrovirus replication and transposition of endogenous retroelements (1) . One family member, APOBEC3A (hA3A), is an orphan, without any known antiviral activity. We show that hA3A is...
A new study has demonstrated that African village weaver birds ( Ploceus cucullatus ) show less individuality in the appearance of their eggs when freed from the threat of raising the young of egg-mimicking diederik cuckoos ( Chrsococcyx caprius ). This suggests another clear example of natural...
A new series of major prizes to boost research in areas such as mass human genome sequencing is under way. Nigel Williams reports.
The origin-recognition complex (ORC) has an essential role in defining DNA replication origins (1) and in chromosome segregation (2, 3) . Recent studies in Drosophila orc2 mutants (4–6) , and in human cells depleted of ORC2 (3) , have suggested that this factor is also implicated in mitotic...
The increase in the global atmospheric CO 2 concentration projected for 2050 increases the productivity of temperate forests by a quarter; but it is by no means clear that such increased productivity will lead to more long-term carbon sequestration.
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