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A recent study indicates that the genomic mutation rate of the gut bacterium Escherichia coli is substantially higher in nongrowing than growing cultures. These findings are important in the light of the ongoing controversy over the generality and robustness of stationary phase mutagenesis and...
Background: The protein phosphatase Cdc14 is a key regulator of exit from mitosis in budding yeast. Its activation during anaphase is characterized by dissociation from its inhibitor Cfi1/Net1 in the nucleolus and is controlled by two regulatory networks. The Cdc14 early anaphase release (FEAR)...
Mediawatch: Following field-scale trials, a leaked report suggests the British government is set to back the first commercial planting of a genetically modified crop. Bernard Dixon reports on the press's explosive response.
Background: Behavioral responses to odorants require neurons of the higher olfactory centers to integrate signals detected by different chemosensory neurons. Recent studies revealed stereotypic arborizations of second-order olfactory neurons from the primary olfactory center to the secondary...
A growing body of neuroimaging and neurophysiology studies has demonstrated the motor system's involvement in the observation of actions (1–5) , but the functional significance of this is still unclear. One hypothesis suggests that the motor system decodes observed actions (6, 7) . This...
Introns are flanked by a partially conserved coding sequence that forms the immediate exon junction sequence following intron removal from pre-mRNA. Phylogenetic evidence indicates that these sequences have been targeted by numerous intron insertions during evolution, but little is known about...
Bacterial cells exhibit a wide variety of shapes. Recent results indicate that the characteristic crescent shape of Caulobacter crescentus depends upon an inter-mediate filament-like protein that localizes to the concave side of the cell.
A new biography of Alfred Russel Wallace, co-founder of the theory of natural selection, aims to throw light on the key interaction and special relationship with Charles Darwin. Nigel Williams reports.
Genome sizes vary enormously. This variation in DNA content correlates with effective population size, suggesting that deleterious additions to the genome can accumulate in small populations. On this view, the increased complexity of biological functions associated with large genomes partly...
Protein inclusions are associated with a number of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) (1) . Whether protein aggregates are toxic or beneficial to cells is not known. In ALS animal models, mutant SOD1 forms aggresome-like structures in motor neurons and...
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