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After its specification, the Drosophila oocyte undergoes a critical polarization event that involves a reorganization of the microtubules (MT) and relocalization of the determinant Orb within the oocyte. This polarization requires Par-1 kinase and the PDZ-containing Par-3 homolog, Bazooka (Baz)....
Background: Meiotic pairing is essential for the proper orientation of chromosomes at the metaphase plate and their subsequent disjunction during anaphase I. In male Drosophila melanogaster , meiosis occurs in the absence of recombination or a recognizable synaptonemal complex (SC). Due to...
To establish the major body axes, late Drosophila oocytes localize determinants to discrete cortical positions: bicoid mRNA to the anterior cortex, oskar mRNA to the posterior cortex, and gurken mRNA to the margin of the anterior cortex adjacent to the oocyte nucleus (the “anterodorsal...
With developments in genetics, researchers are increasingly able to address historical issues surrounding human migration and provenance by studying present populations. Nigel Williams reports on one of the latest studies looking at a crucial period of British history.
The biogenesis of microtubules comprises several steps, including the correct folding of α- and β-tubulin and heterodimer formation. In vitro studies and the genetic analysis in yeast revealed that, after translation, α- and β-tubulin are processed by several chaperonins (1, 2) and...
Light provides a major source of information from the environment during plant growth and development (1, 2) . Recent results suggest that the key events controlling light-regulated gene expression in plants are translocation of the phytochrome photoreceptors into the nucleus, followed by their...
Coloured flashes that are visible only to the short-wavelength-sensitive S cones interfere with shifts of visual attention but not with shifts of gaze (saccades). Attention and gaze must therefore be directed by different visual sub-systems.
Neurophysiological studies in human patients, with experiments of the kind traditionally reserved for monkeys, are beginning to provide valuable insight into the workings of the brain. Taking center stage is the question of which neurons lie at the heart of perception itself.
Vimentin intermediate filaments move bi-directionally along microtubules in the cell. Recent work has identified the microtubule motor cytoplasmic dynein as the missing inward-directed motor that drives this movement.
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