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The specific effects of some mutations that cause cystic fibrosis suggest that reduced HCO 3 − transport is the key to understanding cystic fibrosis pathology. But there is a puzzling discrepancy between measures of CFTR-mediated chloride conductance in expression systems and the sweat chloride...
Background: Cranial neural-crest (CNC) cells originate from the lateral edge of the anterior neuroepithelium and migrate to form parts of the peripheral nervous system, muscles, cartilage, and bones of the face. Neural crest-cell migration involves the loss of adhesion from the surrounding...
Nijmegen breakage syndrome (NBS) is a rare human disease displaying chromosome instability, radiosensitivity, cancer predisposition, immunodeficiency, and other defects (1, 2) . NBS is complexed with MRE11 and RAD50 in a DNA repair complex (3–5) and is localized to telomere ends in association...
Background: The biological clock synchronizes the organism with the environment, responding to changes in light and temperature. Drosophila CRYPTOCHROME (CRY), a putative circadian photoreceptor, has previously been reported to interact with the clock protein TIMELESS (TIM) in a light-dependent...
The AP-1 adaptor complex has been cast as the major player in clathrin coat formation for vesicular transport from the trans -Golgi to the endocytic pathway. But new results on ‘GGA’ proteins have raised doubts about this paradigm and suggest both a new sorting mechanism and an unexpected...
Centrioles are among the most beautiful and mysterious of all cell organelles. Although the ultrastructure of centrioles has been studied in great detail ever since the advent of electron microscopy, these studies raised as many questions as they answered, and for a long time both the function...
Background: In Saccharomyces cerevisiae the mitotic-exit network (MEN) functions in anaphase to promote the release of the Cdc14p phosphatase from the nucleolus. This release causes mitotic exit via inactivation of the cyclin-dependent kinase (Cdk). Cdc14p-like proteins are highly conserved;...
Together with some aquatic mammals, birds exhibit a unique behavioral and electrophysiological state called “unihemispheric sleep,” in which one cerebral hemisphere is awake and the other is sleeping (1) . Slow-wave sleep in one hemisphere is associated with closure of the contralateral eye,...
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