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The tumor microenvironment, or stroma, is known to contribute to tumor progression. Two recent studies have shown that the stromal protein matrix metalloproteinase MMP-9 has a role in the early stages of tumor growth and angiogenesis.
Systemic lupus erythematosus (SLE) is an autoimmune disease whose cause is poorly understood. Mice rendered deficient in specific genes have served as useful animal models in deciphering the genetic control of the disease (1) . We (2) and others (3, 4) previously demonstrated that mice deficient...
The tiny island has invested heavily in life sciences as a linchpin of its future economy. But initial enthusiasm for a broad-based approach has switched to a focus on human healthcare, reports Kenneth Lee.
Associating information with vivid sensory cues aids recall of that information. New experiments help shed some light on the brain mechanisms of memory retrieval that make this mnemonic technique so effective.
Recent results suggest that stem cells from one tissue can give rise to cells from developmentally unrelated tissues. These results strongly support the idea that certain progenitors retain much broader developmental potentials than expected, and other progenitors may be able to acquire broader...
The mechanism of centrosome inheritance during parthenogenetic development has long been an outstanding mystery of cell biology. New observations of centrosome inheritance in hymenopterans have provided our first direct insights into this enigmatic process.
With the first draft of the human genome completed, Michael Gross looks at some of the plans to study a variety of European populations to exploit the new information.
Background: In response to DNA damage, fission yeast, mammalian cells, and cells of the Drosophila gastrula inhibit Cdk1 to delay the entry into mitosis. In contrast, budding yeast delays metaphase-anaphase transition by stabilization of an anaphase inhibitor, Pds1p. A variation of the second...
Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial polyposis, a form of inherited colon cancer. In addition to its role in mediating β-catenin degradation in the Wnt signaling pathway, APC plays a role in regulating microtubules. This was suggested...
Background: In the leech Helobdella robusta , an annelid worm, the early pattern of cell divisions is stereotyped. The unequal first cleavage yields cells AB and CD, which differ in size, cytoplasmic inheritance, normal fate, and developmental potential. Results: Here we report a dynamic and...
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