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Recent findings indicate that the dynamin GTPase helps to divide animal and fungal mitochondria, and that the tubulin-like FtsZ GTPase is involved in division of, not only most bacteria, but also chloroplasts and probably mitochondria of unicellular eukaryotes.
Classically, monocular deprivation leaves all layers of visual cortex dominated by the non-deprived eye. Unexpectedly, the changes first appear in the outer layers, not the central input layer. Do thalamocortical and corticocortical synapses differ in their plasticity and could the outer layers...
While antigen-inexperienced (naive) T cells appear to require constant tickling of their receptor by self-antigens for homeostasis, antigen-experienced (memory) T cells have no such requirement. An implication is that long-term T-cell memory does not depend on persisting antigen.
Niemann–Pick type C (NP-C) disease is a progressive neurodegenerative disorder characterized by the inappropriate accumulation of unesterified cholesterol in lysosomes (1) . NP-C patients show various defects including hepatosplenomegaly, ataxia, dystonia and dementia. Most cases of NP-C are...
Background: Myosin II, a conventional myosin, is dispensable for mitotic division in Dictyostelium if the cells are attached to a substrate, but is required when the cells are growing in suspension. Only a small fraction of myosin II-null cells fail to divide when attached to a substrate....
The vertebrate body plan arises during gastrulation, when morphogenetic movements form the ectoderm, mesoderm, and endoderm. In zebrafish, mesoderm and endoderm derive from the marginal region of the late blastula, and cells located nearer the animal pole form the ectoderm (1) . Analysis in...
Background: Human epidermis is renewed throughout life from stem cells in the basal layer of the epidermis. Signals from the surrounding keratinocytes influence the differentiation of the stem cells, but the nature of the signals is unknown. In many developing tissues, signalling mediated by the...
The MDM2 protein targets the p53 tumor suppressor for ubiquitin-dependent degradation (1) , and can function both as an E3 ubiquitin ligase (2) and as a regulator of the subcellular localization of p53 (3) . Oncogene activation stabilizes p53 through expression of the ARF protein (p14 ARF in...
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