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Sphingosine kinase (SphK) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). S1P/SphK has been implicated as a signalling pathway to regulate diverse cellular functions (1–3) , including cell growth, proliferation and survival (4–8) . We...
Background: Two genetic ‘pathways’ contribute to the fidelity of nuclear segregation during the process of budding in the yeast Saccharomyces cerevisiae . An early pathway, involving Kar9p and other proteins, orients the mitotic spindle along the mother–bud axis. Upon the onset of anaphase,...
The idea of using simple, genetically tractable host organisms to study the virulence mechanisms of pathogens dates back at least to the work of Darmon and Depraitère (1) . They proposed using the predatory amoeba Dictyostelium discoideum as a model host, an approach that has proved to be valid...
Recent studies have suggested that proteins found at the tips of microtubules in vertebrate cells may play an important role in intracellular membrane transport processes. Evidence from fission yeast indicates that such proteins can also regulate microtubule dynamics.
The neglect of one side of space exhibited by some brain-damaged patients can be ameliorated by cueing the patient to the neglected side of space. A related effect has been found to depend on the hand being seen and felt at the same time. The results add to a growing literature on...
Remodeling of filamentous actin into distinct arrangements is precisely controlled by members of the Rho family of small GTPases (1) . A well characterized member of this family is RhoA, whose activation results in reorganization of the cytoskeleton into thick actin stress fibers terminating in...
The eight photoreceptors in each ommatidium of the Drosophila eye are assembled by a process of recruitment (1,2) . First, the R8 cell is singled out, and then subsequent photoreceptors are added in pairs (R2 and R5, R3 and R4, R1 and R6) until the final R7 cell acquires a neuronal fate. R7...
Background: The development of a connection between the uterus and the vulva in the nematode Caenorhabditis elegans requires specification of a uterine cell called the utse, and its attachment to the vulva and the epidermal seam cells. The uterine π cells generate the utse and uv1 cells, which...
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