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The visual system is constantly faced with the problem of identifying partially occluded objects from incomplete images cast on the retinae. Phenomenologically, the visual system seems to fill in missing information by interpolating illusory and occluded contours at points of occlusion, so that...
The establishment of the anterior–posterior (AP) axis in Drosophila melanogaster requires signaling between the oocyte and surrounding somatic follicle cells during oogenesis (1,2) . First, a signal from the oocyte (Gurken (Grk), a transforming growth factor-α (TGFα) homolog) is received by...
Background: The final shape and size of an organism is determined by both morphogenetic processes and cell proliferation and it is essential that these processes be properly coordinated. In particular, cell division is incompatible with certain types of morphogenetic cell behaviour, such as...
The mitochondrial protein import machinery specifically recognizes many different preproteins lacking a consensus sequence. The three-dimensional structure of an import receptor complexed to an amino-terminal targeting ‘presequence’ provides exciting insight into the molecular mechanism of...
New insight into how the brain makes a decision has come from a study of the effects of the decision-making process on an eye movement evoked by electrical stimulation of the frontal cortex. The accumulation of sensory evidence was found to cause a gradual commitment toward a choice.
Transport vesicles are tethered to their target membrane prior to the interaction of v-SNAREs and t-SNAREs across the membrane junction. Recent evidence suggests tethering is a complex process requiring multiple components.
Notch signalling is best known for its role in lateral inhibition, where it acts to prevent differentiation of cells neighbouring one that has ‘won out’ in a competition to differentiate. Recent results suggest that Notch signalling can work in the opposite way, and promote differentiation of...
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