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Crystal structures have been solved for two bacterial outer membrane proteins, FhuA and FepA, which mediate active transport of chelated iron. Analysis of ligand-induced changes in the structure of FhuA has provided our first structural insights into an active transport mechanism for a complex...
The epidermis is a multilayered squamous epithelium in which dividing basal cells withdraw from the cell cycle and progressively differentiate as they are displaced toward the skin surface. Eventually, the cells lose their nucleus and other organelles to become flattened squames, which are...
A picture is emerging of how HIV subverts a normal immunological surveillance mechanism to establish primary infection. This involves the infection of dendritic cells at mucosal surfaces: as these cells then mature, they transport the virus to lymphoid tissue, where viral replication begins and...
Microtubule-associated proteins (MAPs) have been identified as binding partners for ionotropic GABA A and GABA C receptors. These interactions suggest a potential role for MAPs in the cytoskeletal anchoring of receptor-ion channels at specific subcellular sites, such as synapses.
Ubiquitin-dependent proteolysis plays an important role in cell-cycle control (1,2) . In budding yeast, the protein Skp1p, the cullin-family member Cdc53p, and the F-box/WD-repeat protein Cdc4p form the SCF Cdc4p ubiquitin ligase complex, which targets the cyclin-dependent kinase (Cdk) inhibitor...
In recent years, a large number of coiled-coil proteins localised to the Golgi apparatus have been identified using antisera from human patients with a variety of autoimmune conditions (1) . Because of their common method of discovery and extensive regions of coiled-coil, they have been...
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