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The mouse midbrain–hindbrain constriction is centrally involved in patterning of the midbrain and anterior hindbrain (cerebellum), as revealed by recent genetic studies using mice and embryological studies in chick (reviewed in (1,2) ). This region can act as an organizer region to induce...
Recent results reinforce the view that actin-based and microtubule-based motility systems do not operate independently, but are used in a coordinated fashion to determine intracellular localization of cargo such as organelles.
SNARE proteins are sufficient to fuse artificial membranes together. In the cell, vesicle transport may rely on fusion mediated by interaction between vesicle (v) and target (t) SNAREs, whereas the homotypic fusion of organelle biogenesis may be mediated by t-SNARE–t-SNARE interaction.
We have shown previously that fibroblast growth factor (FGF) signalling in posterior regions of the Xenopus embryo is required for the development of the trunk and tail via a molecular pathway that includes the caudal -related gene Xcad3 and the posterior Hox genes (1) . These results have been...
The N-myc proto-oncogene is expressed in many organs of the mouse embryo, suggesting that it has multiple functions. A null mutation leads to mid-gestation lethality (1–4) , obscuring the later roles of the gene in organogenesis. We have generated a multi-purpose gene alteration by combining...
A factor has been purified that specifically facilitates RNA chain elongation in a chromatin context; the properties of this factor help to define the challenges that lie ahead in understanding how RNA polymerase manages to transcribe DNA that is packaged into chromatin.
Nucleocytoplasmic transport involves assembly and movement across the nuclear envelope of cargo–receptor complexes that interact with the small GTPase Ran. The asymmetric distribution of Ran regulator proteins, RanGAP1 and RCC1, provides the driving force and directionality for nuclear transport.
Background: The Cut1 and Cut2 proteins of the fission yeast Schizosaccharomyces pombe form a complex and are required for the separation of sister chromatids during anaphase. Polyubiquitinated Cut2 degrades at the onset of anaphase and this degradation, like that of mitotic cyclin, is dependent...
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