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Arguments based on mathematical topology may help in understanding the organization of topographic maps in the cerebral cortex.
Background: The structural proteins of human immunodeficiency virus type 1 (HIV-1) are encoded by intron-containing mRNAs that normally are retained in the nucleus. A viral regulatory protein, Rev, specifically induces the accumulation of these transcripts in the cytoplasm. Rev is an RNA-binding...
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells provide immune surveillance against viruses and neoplasms, and play a central role in the pathogenesis of autoimmune disease, AIDS and graft rejection (1,2) . Thus, it is important to understand the precise molecular mechanism(s)...
A recent study shows that sphingosine kinase and its lipid product have an essential signalling function; they act in the mobilization of calcium ions in antigen-stimulated mast cells. This finding may have relevance to signalling in other cells of the immune system.
Background: Glycoproteins encoded by the major histocompatibility complex class I region (MHC class I) present peptide antigens to cytotoxic T cells (CTLs). Peptides are delivered to the site of MHC class I assembly by the transporter associated with antigen processing (TAP), and cell lines that...
Translation of the transcription factor caudal is repressed at the anterior end of the Drosophila embryo. Surprisingly, the DNA-binding homeodomain of the transcription factor Bicoid mediates this repression by binding caudal mRNA.
Neuropsychological studies of people with specific brain lesions have led to the theory that different parts of the brain are responsible for recognizing living and non-living objects. Now there is direct evidence from activity measurements that this is the case.
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