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The assembly of condensed chromosomes in a cell-free system is inhibited by the addition of proteins that bind AT-rich DNA. Does this implicate the AT-rich scaffold attachment regions (SARs) in the formation of chromosomes?
The cloning of genes needed for gentle-touch sensitivity in the nematode Caenorhabditis elegans has provided new molecular details about a proposed mechanosensory ion channel complex.
Recent results show that immune responses can be induced in neonatal mice. Do they really refute the traditional view that the ability to discriminate between ‘self’ and ‘non-self’ is a fundamental property of the immune system?
The tumor suppressor gene encoding the cyclin-dependent kinase inhibitor p16 has, remarkably, been found to encode a second protein, p19, with a distinct sequence translated from an alternative reading frame; like p16, p19 can block the cell cycle in G1 phase.
Background: The budding yeast Saccharomyces cerevisiae can bud in two spatially programmed patterns: axial or bipolar. In the axial budding pattern, cells polarize and divide adjacent to the previous site of cell separation, in response to a cell-division remnant, which includes Bud3p, Bud4p and...
Background: Activated receptor tyrosine kinases bind downstream effector molecules with high affinity. Provided that they can be introduced into cells, peptides corresponding to these high-affinity sites should be able to compete for the interaction and thereby inhibit specific signal...
The solution structure of the complex between a peptide derived from the bovine immunodeficiency virus tat protein and the TAR RNA to which it binds reveals a new motif in protein–RNA interactions.
Apoptosis, or programmed cell death, is the physiological process whereby individual cells are deliberately eliminated to achieve homeostasis and proper metazoan development. Numerous genes have recently been identified that are involved in apoptosis: some are believed to encode death effectors,...
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