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Recent neurophysiological studies reveal both spatial and feature-based processes for directing visual attention; they also suggest ways of analyzing how these processes interact and govern the flow of sensory information to higher cortical centers.
Recent crystal and solution structures of components of the core transcription initiation complex that assembles at RNA polymerase II promoters reveal similarities to core histones and cyclin A.
Background: Retinoic acid (RA) is a morphogenetically active signalling molecule thought to be involved in the development of several embryonic systems (based on its effect when applied in excess and the fact that it can be detected endogenously in embryos). Here, we adopt a novel approach and...
Recent studies have shown that the CTLA-4 high avidity receptor for the B7 family of T-cell costimulatory molecules is also a powerful negative regulator of T-cell activation and autoreactivity.
Background: In the budding yeast, Saccharomyces cerevisiae , each DNA replication origin is associated with an autonomously replicating sequence (ARS) element. Each element contains several modules, including an essential close match to the 11 base-pair (bp) ARS consensus sequence (ACS) and two...
Background: The transition from G1 to S phase is the key regulatory step in the mammalian cell cycle. This transition is regulated positively by G1-specific cyclin-dependent kinases (cdks) and negatively by the product of the retinoblastoma tumour suppressor gene, pRb. Hypophosphorylated pRb...
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