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Phosphoinositide 3-kinase, an enzyme that is known to transduce signals received by a variety of receptor types, has been found to mediate agonist-dependent membrane ruffling via the small GTP-binding protein Rac.
Protein kinase A activity is required for signalling by the extracellular molecule Hedgehog in developing Drosophila imaginal discs, but does the kinase actually respond to the Hedgehog signal?
Many proteins that resemble Bcl-2 or bind to it have been found using techniques that reflect interactions in vitro or depend on DNA homology, but we still do not know how this master regulator of apoptosis works.
Recent studies of the neural mechanisms of avian song learning suggest that pathways for adult song production are distinct from those essential to juvenile song development.
An old idea about the relationship between arthropod and vertebrate body plans has been given new life by studies of the signalling genes controlling dorsal and ventral development in Drosophila and Xenopus .
Background: The differentiation of floor plate cells and motor neurons in the vertebrate neural tube appears to be induced by signals from the notochord. The secreted protein encoded by the Sonic hedgehog (Shh) gene is expressed by axial midline cells and can induce floor plate cells in vivo and...
Integrins use divalent cations, held within a novel ‘MIDAS’ motif, for ligand binding. It is proposed that a missing coordination site for the cation is provided by a critical acidic residue in the ligand.
Background: The adhesion molecule L-selectin is expressed on the cell surface of lymphocytes and mediates their migration from the bloodstream into lymph nodes. L-selectin is able to recognize four glycoprotein ligands, three of which — Sgp50, Sgp90 and Sgp200 — are sulphated, bind...
Background: The subdivision of T cells into αβ and γδ subtypes is conserved throughout vertebrate development. The respective αβ and γδ T-cell receptors (TCRs) are encoded by somatically rearranged genes. There has been broad speculation as to whether an individual thymocyte can become...
Transfection studies provide supporting evidence for the proposed role of villin and fimbrin in bundling the core actin filaments of microvilli.
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