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Administration of the VEGF receptor blocker SU5416 to rats causes alveolar septal cell apoptosis and emphysema; both can be prevented by a superoxide dismutase mimetic. Here we show that SU5416 induces the expression of heme oxygenase‐1 in the lung tissue and that administration of antioxidant...
This article represents a commentary on a controversial hyphothesis described by Dr.Milic‐Emili in this issue. The authors discuss the hyphothesis and suggest that a re‐examination of longitudinal lung function data could prove or deny his suggestion.
Study Objective . COPD mortality alone among major causes of diseases continues to rise in most countries worldwide. We examine trends, and gender and ethnic differences in COPD hospitalization and mortality in Singapore from 1991 to 1998, and examine possible explanations. Design . Analysis of...
In the present account it is proposed that in smokers the transition from peripheral airway disease to COPD is characterized by three sequential stages: Stage I , during which the closing volume eventually exceeds the functional residual capacity; Stage II , during which tidal expiratory flow...
The archetypal status of α 1 ‐antitrypsin in biology and medicine grew from the finding, thirty years ago, by Carl‐Bertil Laurell, of the association of its deficiency with emphysema. In biology, α 1 ‐antitrypsin now provides the model for both the structure and the remarkable mechanism...
Non‐compliance or euphoria may limit the usefulness of prednisolone tablets in assessing steroid‐responsiveness in chronic obstructive pulmonary disease (COPD). Depot intra‐muscular methyl‐prednisolone (imMP), producing a plateau steroid effect over two weeks, may be more reliable....
An imbalance between proteases and anti‐proteases is believed to play an important role in the pathogenesis of emphysema. In this study, we explored the hypothesis that cigarette smoke can alter tissue structure through an effect on the release of matrix metalloproteinase‐1 (MMP‐1) and type...
Alveolar macrophages play a critical role in the pathophysiology of COPD and are a major target for future anti‐inflammatory therapy. Macrophage numbers are markedly increased in the lung and alveolar space of patients with COPD and are localized to sites of alveolar destruction. The increased...
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