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A case is presented of a 76-year-old male who ingested Nicotiana glauca and developed severe nicotine-alkaloid toxicity primarily characterized by neuromuscular blockade and respiratory failure. Recovery occurred with supportive care.
The pharmacokinetics of prunasin have been investigated in the dog. The results are compared with results obtained with amygdalin. The volume of distribution and the clearance of prunasin are larger than those of amygdalin. The oral bioavailability of prunasin is approximately 50%, whereas...
Methylmercury (MM) is a very potent neurotoxic agent. Its role in polluting the environment is well documented. A vast amount of study over the past several decades has finally provided insight into many aspects of its effect. Exposure to MM may be through ingestion of poisoned fish or...
Phencyclidine (PCP) concentrations have been studied in the blood and tissues of Los Angeles County victims whose deaths were related to PCP use. In most cases PCP blood concentrations ranged from 0.01 to 0.9 μ g/mL while higher concentrations were found in the liver, urine, bile, brain, and...
Deferoxamine, a specific chelator of ferric iron, has recognized efficacy in the treatment of acute iron overdosage. Toxicological references, however, vary in the preferred route of administration and recommended maximum dosage. A 19-year-old female patient ingested an estimated 50-60 ferrous...
Ingestion of paraquat results in an extremely dangerous poisoning. The first aim is to clear the gastrointestinal tract by inducing emesis and performing gastric/gut lavage; as much activated charcoal as possible should be administered per os and as quickly as possible. The best measure to...
In a drug abuse treatment service, patients were monitored for urine PCP over extended time periods. Thirty subjects who had two consecutive negative results followed by a positive result are discussed as are the possible causes of the positive values.
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