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Objective The objective of this post hoc analysis was to investigate the effect of strontium ranelate on a cartilage degradation marker in postmenopausal women who participated in a randomized, placebo-controlled osteoporosis study. Women were stratified according to reported symptoms of...
Background There are many effects described, both experimental and clinical, that assess the relationship between isoflavones and bone. It has been hypothesized that isoflavones may have a positive effect on bone health. Objective To review the effects of isoflavones on biochemical markers of...
The latest recommendations on postmenopausal hormone therapy (HT) stress the need first to evaluate the individual benefits and risks and to prescribe the well-informed patient only when the balance is most favorable. As a result of recent studies on the association of lung cancer with HT, this...
Vitamin D is principally obtained from skin through the action of ultraviolet B irradiation on 7-dehydrocholesterol. It is further metabolized to 25-hydroxyvitamin D, the major circulating vitamin D compound, and then to 1,25-dihydroxyvitamin D, the hormonal form. The major function of vitamin D...
The recent report of a two-fold increase in esophageal cancer in women taking oral bisphosphonates is yet another reason to question current relegation of hormone replacement therapy (HRT) to a minor role in the correction of many problems occurring in the younger postmenopausal woman. Women...
Objective A major impediment in osteoporosis care is poor therapeutic adherence. Real-life surveys show that adherence and persistence with oral bisphosphonates decrease to 30––60%% within 1 year. The aim of this study was to analyze the adherence and persistence with raloxifene in patients...
The incidence of meningiomas is two to three times higher in women than in men, yet it is a rare event (around one case per 10 000 woman-years). Preclinical and clinical studies point at potential effects of female sex hormones on brain tumors. Results from several prospective, large-scale...
Objective . To assess risk factors associated with low bone mineral density (BMD) in postmenopausal women. Methods . In this cross-sectional study, a total of 412 Brazilian postmenopausal women, aged 40––75 years, with BMD measured using central dual-energy X-ray absorptiometry, were...
Objective To estimate the prevalence of depression in postmenopausal women and to evaluate the relation between postmenopausal depression and some sociodemographic characteristics. Methods This cross-sectional study was conducted in 744 postmenopausal women aged 45––65 years residing within...
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