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Objective To determine whether a training state protects against the metabolically deleterious effects of ovariectomy on liver and adipocyte fat accumulation in rats. Design Female rats were randomly assigned to each group ( n = 8 rats/group). The animals were first either exercise-trained (Tr)...
The prevalence of obesity is rising dramatically, impacting adversely on health and well-being at the menopause and across the lifespan. With menopause, abdominal adiposity selectively increases. The impact of obesity and abdominal adiposity on chronic disease, including diabetes and...
Setting Hormone therapy used for the management of postmenopausal symptoms in older women appears to result in variable effects on cognitive function, depending on study design, subjects, tests used, and types of therapy. Objective To determine the effects of estrogen-only and estrogen plus...
Background Literature suggests that muscle-tendon unit (MTU) stiffness is implicated in human motion performance and injuries. In addition, muscle and joint pains comprise a set of very common climacteric symptoms. Concomitant with such symptoms, physical fragility and mobility limitations are...
Objective To determine whether the prescribing practice of physicians with regard to estrogen replacement therapy (ERT) in symptomatic women with previous endometrial cancer is consistent with the available evidence. Methods A descriptive survey was conducted among physicians in Germany, using a...
Objectives First, to investigate cross-cultural variations in symptom prevalence for mid-life women using data from studies undertaken in the UK, Japan, China, Canada and the USA, and, second, to examine the relationship between symptoms, ethnicity, age and menopausal status for London's...
Objective The objective of the study was to evaluate the endometrial safety of a 10 μg estradiol vaginal tablet in the treatment of vaginal atrophy in postmenopausal women. Methods A total of 336 healthy, non-hysterectomized, postmenopausal women (age 59.5 ± 6.16 years, 9.4 ± 5.9 years from...
Objectives The study aimed to compare measurements of coronary artery calcification (CAC) and bone mineral density (BMD) in postmenopausal women. Methods The CAC of the women was measured with electron beam tomography using a GE Imatron C150 XP EBT scanner. Subjects with calcium scores above 0...
Several new selective estrogen receptor modulators (SERMs) are currently under clinical development for the prevention and/or treatment of postmenopausal osteoporosis, with the goal of optimizing the estrogen receptor agonist/antagonist activity in target tissues. Bazedoxifene is a novel SERM...
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