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Objective This systematic evidence review evaluates the independent influence of the menopausal transition on mood including depression, anxiety, and other psychological symptoms. Methods Community-based, prospective cohort studies of mid-life women transitioning through menopause that assessed...
Objectives Equol, a gut bacterial metabolite of the isoflavone daidzein, has been associated with beneficial health effects. Recent studies indicate that women with intestinal capacity to convert daidzein to equol also have the capacity to alter steroid metabolism and bioavailability of...
Background In a follow-up study of 948 576 women, based on respective relative risk (RR) estimates of 1.23 and 1.20 for incident and fatal ovarian cancer among current users of postmenopausal hormone therapy (HT), the Million Women Study investigators have estimated that, since 1991, HT has...
Objective To study the influence of smoking on uterine bleeding patterns during continuous and interrupted oral hormone therapy (HT). Methods Using a post-hoc strategy, we included five oral HT groups from three studies. The therapies consisted of continuous estrogen (estradiol, estradiol...
Objective To compare the effects of raloxifene and soy phytoestrogens on endothelial function in healthy, postmenopausal women. Design Randomized, double-blind, placebo-controlled, cross-over trial. Subjects ( n = 22; mean age 58.5 years) underwent endothelial function testing at baseline and...
Cardiovascular risk is poorly managed in women, especially during the menopausal transition when susceptibility to cardiovascular events increases. Clear gender differences exist in the epidemiology, symptoms, diagnosis, progression, prognosis and management of cardiovascular risk. Key risk...
Objectives To examine the association of alcohol consumption with well-being in mid-aged Australian women, taking into account other lifestyle factors. Methods A prospective, observational study was carried out among 438 urban Australian women aged 45–55 years at baseline. They were assessed...
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