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Fotemustine is a relatively novel DNA-alkylating 2-chloroethyl-substituted N -nitrosourea (CENU) drug, clinically used for the treatment of disseminated malignant melanoma in different visceral and non-visceral tissues. Thrombocytopenia has been observed in patients treated with fotemustine and...
Estrogens, used widely from hormone replacement therapy to cancer treatment, are themselves carcinogenic, causing uterine and breast cancers. However, the mechanism of their carcinogenic action is still not known. Recently, we found that estrone (E 1 ) and 17 β -estradiol (E 2 ) could be...
Green tea extract and its polyphenolic components have been found to possess anticarcinogenic, antimutagenic, antihypertensive and antihepatotoxic effects, and several mechanisms have been proposed for these effects. In this study, the effects of five tea polyphenols,...
The GSH dependence of the metabolic pathways involved in the conversion of cysteine to sulfate in intact cells has been investigated. It was found that hepatocyte-catalysed sulfate formation from added l -cysteine did not occur if hepatocyte GSH was depleted beforehand, but was restored when GSH...
This report presents a comparison of the effects of cis - and trans -diamminedichloroplatinum complexes on in vitro platelet functions. Pretreatment of platelets with cis -platinum ( cis platin) induced a slow, dose-dependent (0.1–0.45 mM), increase in the cytosolic Ca 2+ concentration,...
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