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Abstract. Cells growing in tissue culture as three-dimensional, multicellular aggregates called ‘spheroids’ typically show a decreasing growth fraction and development of quiescent subpopulations as the spheroids enlarge. Kinetic studies in a number of spheroid systems have indicated that the...
Book reviewed in this article: Protein-Nucleic Acid Interaction. Edited by W. Saenger & U. Heinemann. Membrane Fusion in Fertilization, Cellular Transport and Viral Infection. Current topics in Membranes and Transport, Volume 32. Edited by N. Duzgunes & F. Bronner.
9th Summer Symposium in Molecular Biology Molecular Pathways of Cell Growth Control 2nd International Conference on Negative Regulators of Hematopoiesis European Hair Research Society
Abstract. This study was performed to determine the colony and cluster forming ability of granulocyte-macrophage (CFU-GM) progenitors of normal human blood low density cells cultured in a liquid culture system in the presence and absence of physiological doses of hydrocortisone (He). The CFU-GM...
Abstract. To elucidate the role and quantitative contribution of several exogenous factors which may regulate colon crypt mitotic activity, proliferative zone height (PZH) and crypt height, groups of rats were subjected to various feeding regimens both with and without treatment with the colon...
Abstract. A method is described to combine tritiated thymidine autoradiography with immunoperoxidase detection of bromodeoxyuridine on the same paraffin sections. It overcomes the varied technical artefacts we encountered when first attempting to combine these techniques and results in...
Abstract. A model-independent and elementary method of analysis of platelet survival is proposed. The method is based on the finding that the mean and standard deviation of the platelet lifespan can be expressed in the terms of the slope at time 0 and the area under the empirical platelet...
Abstract. The present experiments with (14C)-thymidine (TdR) and (3H)-bromo-deoxyuridine (BrdU) using mouse jejunal crypt cells show that the upper limit of the tracer dose of TdR is about 0.5 µg g body weight-1 and that of BrdU is about 5·0 µg g body weight-1. Applying these doses, the...
Abstract. P-30 protein, a novel protein isolated in our laboratory from fertilized Rana pipiens eggs, has been shown to possess significant anti-proliferative and cytotoxic activity against a variety of human tumour cell lines. This protein also shows a potent anti-tumour activity in vivo in...
Abstract. Mitotic cells in normal, mature rat corneal epithelium were examined with a light microscope on serial, semi-thick plastic sections. Classification of mitotic figures into horizontally, obliquely or vertically positioned with reference to the epithelial basal lamina has shown that no...
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