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ABSTRACT The effect of a goitrogenic stimulus on thyroid weight and thyroid cell 3HTdR labeling of Sprague-Dawley rats varying from 2 to 40 weeks of age was determined. Propylthiouracil ad libitum in drinking water produced a spurt in follicle cell labeling index and thyroid weight evident after...
Cell Kinetics in Human Leukaemia. Series haematologica, 1, 3, 1968 (K. G. Jensen and S-A. Killmann, editors).
ABSTRACT The kinetics of spleen colony development has been studied after the injection of 106, 105 and 3 × 104 bone marrow cells. The results indicate that: (1) The CFU population growth rate is independent of cell dose until the logarithmic growth phase is passed. Slowing of growth was seen by...
ABSTRACT Bone marrow plasma cells from fifteen cases of multiple myeloma, immunologically typed, were incubated with different tritiated compounds. The labelling index with tritiated thymidine is generally low, while the mean grain count is fairly normal in the active cells. The labelling index...
ABSTRACT The effect of cortisol administration upon the labelling of blood eosinophils was studied in rats given a single injection of 3H-thymidine. One dose of cortisol did not change the subsequent course of labelling of eosinophils, whereas steroid treatment for 3 days resulted in a delay of...
ABSTRACT RNA was isolated from various mouse tissues 126 days after the injection of 14C-uridine and 37 days after the injection of 3H-uridine. Calculations based on a small but definite residual amount of 14C-labeled RNA suggest the existence of an RNA with a half-life in excess of 10 days....
ABSTRACT Calculations were made based on experimental data of the variation in radiosensitivity and in cell cycle delay with age in Chinese hamster cells (Sinclair, 1967, 1968). The computed syntheses included: (a) single-dose survival curves; (b) splitdose recovery curves, the pattern of...
ABSTRACT 1. Estimates of the number of dividing megakaryocytes with mitotic apparatus have been obtained in intact and in phenylhydrazine-papain treated rats. 2. In treated rats chromosome morphology was studied using colchicine and hypotonic treatment. 3. In bone marrow smears and in cultures...
ABSTRACT HeLa Chessen cells have a doubling time of 18 hr when grown in MEM containing 10% calf serum and antibiotics. When hydrocortisone (1.7 μg/ml) is added to exponentially distributed cells in log growth in this medium, a new pattern of growth begins to emerge after 10–12 hr. This pattern...
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