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Kinins are important peptide mediators of a diverse range of physiological and pathological functions of the cardiovascular system. The kinin peptides exert their effects by selective activation of two distinct G-protein coupled receptors termed B 1 and B 2 . The principal kinin peptides involved...
Background: Although it is known that endothelin (ET-1) is elevated in heart failure (HF), it remains unclear if chronic ET A/B receptor antagonism affects the progression of HF, particularly by affecting coronary vasoactivity and left ventricular (LV) diastolic function. Methods: We examined the...