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Red meat consumption is associated with endogenous metabolic generation of mutagenic N -nitroso compounds (NOC) and may be implicated in causation of colorectal cancer. Assessment of a biologically relevant dose of NOCs is hampered by imperfect understanding of NOC interactions with other dietary...
Loss of connexin expression/gap junction intercellular communication (GJIC) has been correlated with decreased growth control and increased tumorigenesis. Studies utilizing Connexin32 (Cx32)-deficient knockout mice have demonstrated that loss of Cx32 increases susceptibility to chemically induced...
In this study we show that benzo( a )pyrene (B( a )P) and the cyclopenta polycyclic aromatic hydrocarbons (CP-PAH) cyclopenta( c , d )pyrene (CPP), benz( j )aceanthrylene (B( j )A) and benz( l )aceanthrylene (B( l )A) induce apoptosis in Hepa1c1c7 cells, as measured by fluorescence microscopy and...