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2-Amino-3-methylimidazo(4,5- f )quinoline (IQ), a hetero-cyclic aromatic amine that has been identified in cooked meats and cigarette condensates, is mutagenic in human lymphoblastoid TK6 cells at the thymidine kinase and hypoxanthine-guanine phosphoribosyl transferase ( hprt ) loci. Treatment of...
p21 WAF1/CIP1 protein is a cyclin-dependent kinase inhibitor, discovered to be a downstream effector if p53-dependent cell cycle regulation. In order to elucidate the significance of p21 expression in lung adenocarcinomas, we performed immunohistochemical analysis of p21, p53 and Ki-67 expression...
Eukaryotic cell cycle progression is regulated by an orderly and sequential activation of several cyclin-dependent kinases, which phosphorylate key substrates during this process. p34 cdc2 , the catalytic subunit of cdc2 kinase, is expressed at the late G 1 /S boundary and is required for the G 2...