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Four dehydrogenase reactions measured in vitro were used to detect compounds of potential use in the chemotherapy of cancer. Inhibitors of lactate dehydrogenase and L -glycerol-3-phosphate dehydrogenase were sought, based on the proposal that inhibition of these enzymes might be more deleterious...
Data are reported on 993 synthetic compounds which were tested in the CCNSC primary screens. Almost all of the compounds were tested in Sarcoma 180, Adenocarcinoma 755, Leukemia 1210, and KB cells in culture; some tests were also carried out in Friend virus leukemia, Ehrlich ascites, Human...
Seven in vitro enzymatic systems were investigated for the detection of potential cancer chemotherapeutic compounds. The rationale for choosing each enzyme system was that inhibition of the system would have a more adverse effect on the metabolism of the malignant than the normal cell. For each...
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