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Highlights ► Oval cells transfected with HBx were injected intrahepatically or subcutaneously. ► HBx-cells/AFB1 developed intrahepatic tumors with HCC and mesenchymal tumors feature. ► While oval cells produced mesenchymal tumors in subcutaneous tissue. ► Our study illustrated that HCC...
Highlights ► Combination of mTOR inhibitors with Topoisomerase II inhibitors. ► Combination is synergistic in head and neck and breast cancer cells. ► mTOR inhibitor sensitizes adriamycin/cisplatin resistant cells. ► DNA repair is required after induction of DNA damage by topoisomerase II...
Highlights ► RhoGDI2 plays an important role for tumor growth and malignant progression in gastric cancer. ► RhoGDI2 contributes to another important feature of aggressive cancers, i.e., resistance to chemotherapeutic agents. ► Bcl-2 is a major determinant of RhoGDI2-mediated cisplatin...
Highlights ► Thirty-nine of 215 patients exhibited TFPI2 methylation in their serum DNA. ► TFPI2 methylation was observed more frequently according to the cancer progression. ► Using three serum markers including TFPI2 methylation, the detection rate was 42%.
Highlights ► Magnolol repressed HER2 gene expression at the transcription level. ► Magnolol reduced metastatic potential of HER2-positive ovarian cancer cells via modulating the HER2/PI3K/Akt pathway. ► Magnolol induced apoptosis in HER2-positive ovarian cancer cells.
Highlights ► Gene and cell therapy on medullary thyroid carcinoma model cell line TT. ► Fusion yeast cytosine deaminase and prodrug 5-fluorocytosine induced bystander effect. ► Strong tumor xenotransplant growth inhibition upon yCD-TT/5FC combination. ► Inhibition of TT xenotransplant...
Highlights ► In the present study first time we showed the important role of PTTG in the regulation of TGF-β expression and secretion. ► Regulation of TGF-β expression by PTTG resulted in decrease in expression of E-cadherin by regulation of repressor genes Twist, Snail and Slug. ► PTTG...
Highlights ► Internalization and recycling of integrin αvβ6 are detected in colon cancer cells. ► β6-ERK2 binding contributes to the internalization but not the recycling of αvβ6. ► αvβ6 trafficking plays a key role in the migration of colon cancer cells. ► PKC activation...
Highlights ► DNA methylation was analyzed in a cohort of gastric cancer samples and controls. ► ( CHRNA3 and DOK1 ) were identified as new targets of aberrant hypermethylation. ► Age and gender had no significant influence on methylation states. ► LINE-1 and MLH1 methylation correlated...
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