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The results documented that erlotinib at the dose of 100 mg per day, irinotecan 180 mg/m 2 and capecitabine 1,500 mg/m 2 per day for 14 days has an acceptable safety profile and appears suitable for further phase II studies.
These data demonstrate that voreloxin is a broadly active anti-tumor agent in vitro and in vivo, with potent activity in aggressive and drug-resistant tumor models.
Concomitant radiotherapy–fotemustine combination is safe and well tolerated. Overall survival of over 10 months for the whole population compares favorably with other reports.
An extremely high concentration was maintained over 96 h and there was slight transition into general circulation following IT administration. IT paclitaxel might be effective in some patients with ovarian serous adenocarcinoma who have a refractory tumor in the thoracic cavity.
This combination was well tolerated and appears to be a promising treatment for patient with metastatic melanoma.
These results indicated that santamarine, 9β-acetoxycostunolide and 9β-acetoxyparthenolide exhibit significant anticancer activities in vitro. The inhibitory effects of santamarine and 9β-acetoxycostunolide on L1210 cells are cytotoxic rather than just cytostatic. They block mitosis and reduce...
Our results indicate that metronomic capecitabine may be considered a safe and valid treatment option for advanced CRC and gastric cancer patients, both after failure of previous lines of chemotherapy or in front-line when standard chemotherapy is contraindicated, especially when the aim of...
RRM2 gene and protein expression varies by tumor type.
Chemotherapy is an effective anticancer treatment; however, it induces mucositis in a wide range of patients. Mucositis is the term used to describe the damage caused by radiation and chemotherapy to mucous membranes of the alimentary tract. This damage causes pain and ulceration, vomiting,...
Oral administration of DHP 107 provided a substantial systemic absorption of paclitaxel. Furthermore, the relative distribution ratios of DHP 107 at doses of 20 and 40 mg/kg were higher for stomach, small intestine, large intestine, and ovary than the systemic bioavailability, providing a basis...
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