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The sensitivity of detection of anticholinesterase compounds ( e.g. tacrine) by the biochemical method significantly increased when fluorogenic compound N-(4-(7-diethylamino-4-methylcoumarine-3-yl)phenyl)maleimide was used instead of Ellman’s reagent. A kinetic fluorescent method for evaluating...
A method for simulating cardiac hypopolarization arrhythmias was developed in order to study changes in cardiomyocyte membrane hypopolarization under the effects of antiarrhythmics and other drugs. The method is based on registration of K + -induced arrhythmias after intravenous injection of a...
The effect of natural antioxidants in grade III chemical eye burn was studied in experiments on rabbits at various stages of burn disease. The use of histochrome, Gingko Biloba, and diquertin in combination with complex drug therapy decelerated the decrease in the antioxidant potential of tear...
Antinociceptive activity of dalargin (7.5 mg/kg) adsorbed on poly(butyl)cyanoacrylate nanoparticles with different coating was studied on outbred albino mice by the tail-flick test. Poly(butyl)cyanoacrylate nanoparticles without coating did not increase the antinociceptive activity of dalargin...
Intramuscular injection of synthetic analogs of arginine-vasotocin to monkeys after 3% water loading caused antidiuretic reaction, manifesting by reabsorption of osmotically free water and paralleled by significant changes in excretion of sodium or potassium ions. It is shown that synthetic...
The dynamics of structural and functional changes in stellate cells in liver biopsy specimens (from lipid-containing to fibrogenous phenotype) was studied during the development of infectious viral fibrosis and cirrhosis of the liver using ultrastructural, immunohistochemical, and morphometric...
Comparative histological and electron-microscopic studies of tissues at the site of implantation of Vypro and Ultrapro polypropylene mesh endoprostheses and the meshes coated by fibroblasts were carried out. Tissue reaction to implantation of meshes coated by fibroblasts was more pronounced,...
The resistance of August rats to ulceration of the gastric mucosa induced by acute emotional stress was higher than in Wistar rats. August rats exhibited not only more potent activation of the protective nitric oxide system and mobilization of the immune system, but also increased synthesis of...
Full-thickness skin wounds (460 mm 2 ) in rats were associated with increased blood chemiluminescence and neutrophil infiltration of the wound tissue and surrounding skin (recorded by myeloperoxidase activity). Activities of glutathione peroxidase and glutathione S-transferase in the skin and...
The effect of 5-methoxytryptamine (5-HT 4 receptor agonist) on the inotropic function of atrial myocardium was studied in children aged 2 months to 17 years, operated on for congenital heart disease. Functional activity of 5-HT 4 receptors was 8.4 times higher in dysfunction of the atrial septum...
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