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GABA- and cholinergic substances selectively affect different phases of the restoration cycle of primary somatosensory response in albino rats. The GABA antagonist bicuculline reduced and the deactivation inhibitor valproic acid enhanced depression of the test response when stimulated at pulse...
Optimal conditions for measuring 5α-steroid-NAD(P)Δ4-oxidoreductase in primary bone tumors and in normal bone tissues are experimentally chosen in vitro . It is shown that the bone belongs to tissues with low activity of this enzyme. A considerable activation of...
Hypotensive effect of clonidine and its effect on arterial pressure lability as the main index of stability of background blood pressure are studied in intact spontaneously hypertensive rats (SHR) and rats with chronic sinoaortic denervation. Barodenervation potentiates hypotensive and negative...
Female rats aged 3.–3.5 months were daily exposed for 2 h to 2.25% tobacco smoke in a 20-liter chamber for 3 weeks. A week after the beginning of the experiments, all rats were subjected to bilateral oophorectomy. Some of them were injected with estradiol in a daily dose of 2 μg or...
Phenazepam administered in superlow doses exerts an anxiolytic effect in albino male rats under conditions of plus-maze and conflict test and induces typical inhibition of θ-activity in the EEG. Contrary to the effect of usual doses, other frequency intervals remain practically unchanged....
Internal radius, wall thickness, and blood flow rate are measured in rat m. cremaster arterioles of different orders of branching under normal and stepwise decreased arterial pressure. Two types of reactions to a 20% decrease in arterial pressure are observed: active autoregulatory reaction (42%...
Clinically nonphlogogenetic phagocyte reaction under conditions of bacterial challenge was studied in vivo . The “mission” of phagocytes under such conditions is completed by evacuation of phagocytized bacteria from the site of capture into the blood and then into the intestine. The purulent...
In patients with peritonitis, the biological effects of oxygen aeroions reflect the interplay between molecular and cellular effects manifesting themselves in the inhibition of lipid peroxidation, increased antioxidizing potential of blood plasma, and decreased aggregating activity of platelets.
Total and free prostatic specific antigens were measured using heterogeneous two-step streptavidin enzyme immunoassay. Serum concentrations of both antigens were significantly increased in patients with prostatic cancer in comparison with those with benign hyperplasia and controls. The levels of...
Agonists of δ 1 - and δ 2 -opiate receptors prevent epinephrine-induced arrhythmias in rats after intracerebroventricular administration. The antagonist of δ-opiate receptors ICI 174,864 blocks antiarrhythmic effect of the selective agonist of δ-opiate receptors DTLET and exhibits no...
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