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Protein targeting in eukaryotic cells is vital for cell survival and development. N-terminal signal peptides guide proteins to the membrane of the endoplasmic reticulum (ER) and initiate translocation into the ER lumen. Here, we review the status of signal peptide architecture and prediction with...
Identification of reliable molecular markers that show differential expression between distinct groups of samples has remained a fundamental research problem in many large-scale profiling studies, such as those based on DNA microarray or mass-spectrometry technologies. Despite the availability of...