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Programs to import, manage and align sequences and to analyse the properties of DNA, RNA and proteins are essential for every biological laboratory. This review describes two different freeware ( BioEdit and pDRAW for MS Windows) and a commercial program ( Sequencher for MS Windows and Apple...
A scientific database can be a powerful tool for biologists in an era where large-scale genomic analysis, combined with smaller-scale scientific results, provides new insights into the roles of genes and their products in the cell. However, the collection and assimilation of data is, in itself,...
We present our experience of building biological databases. Such databases have most aspects in common with other complex databases in other fields. We do not believe that biological data are that different from complex data in other fields. Our experience has led us to emphasise simplicity and...
The Protein Data Bank (PDB) is a widely used biological database of macromolecular structures with a long history. This history is treated as lessons learned and is used to highlight what are believed to be the best practices important to developers of biological databases today. While the focus...
We describe some of the aspects of Swiss-Prot that make it unique, explain what are the developments we believe to be necessary for the database to continue to play its role as a focal point of protein knowledge, and provide advice pertinent to the development of high-quality knowledge resources...
The World-Wide Web provides a globally distributed communication framework that is essential for almost all scientific collaboration, including bioinformatics. However, several limits and inadequacies have become apparent, one of which is the inability to programmatically identify locally named...
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