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The SLC4A10 gene, which is highly expressed in the mammalian brain, contains two known alternative splicing units, inserts A and B, and is theoretically capable of producing four NBCn2 splice variants: NBCn2-A, -B, -C, and -D. By immunoprecipitation and western blotting, a previous study showed...
Previous studies on laterality in face processing have indicated superiority of the right hemisphere in discriminating and recognizing faces; however, the reasons for this feature are poorly understood. We employed functional MRI (fMRI) to elucidate the origin of this feature and used a...
Redox activity is an important property of living cells, and decreases in redox activity are likely to be an upstream event in ischemic brain injuries. In this study, immediate changes in redox activity caused by ischemic injury were investigated in oxygen–glucose deprivation (OGD) treated...
The dopamine transporter knockout (DAT KO) mouse is a model of chronic hyperdopaminergia used to study a wide range of neuropsychiatric disorders such as schizophrenia, attention deficit hyperactivity disorder (ADHD), drug abuse, depression, and Parkinson's disease (PD). Early studies...
Although the locations of glutamate receptors along the On and Off pathways have been determined, how these receptors modulate the retinal outputs―the light-evoked and spontaneous activities of individual ganglion cells―is not fully understood in the mouse retina. Specifically, how these...
Studies using event related potentials have shown that men are more likely than women to rely on semantic cues when understanding emotional speech. In a previous functional Magnetic Resonance Imaging (fMRI) study, using an affective sentence classification task, we were able to separate areas...
The development of the cancer stem cell (CSCs) niche theory has provided a new target for the treatment of gliomas. Gene therapy using oncolytic viral vectors has shown great potential for the therapeutic targeting of CSCs. To explore whether a viral vector carrying an exogenous Endo–Angio...
LRRC4 is not only a brain-specific gene, but it has also been identified as a tumor suppressor gene for glioma. Promoter methylation of LRRC4 is frequently involved in the inactivation in glioma. MiRNA-mediated gene regulation has recently been demonstrated to play an important role in multiple...
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