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The present study was designed to investigate further the mechanisms involved in the antinociception caused by diphenyl diselenide in behavioral model of pain in mice. Diphenyl diselenide (1–100 mg/kg), given orally, produced significant inhibition of the biting behavior induced by intrathecal...
Batten disease, or juvenile neuronal ceroid lipofuscinosis (JNCL), results from mutations in the CLN3 gene. This disorder presents clinically around the age of 5 years with visual deficits progressing to include seizures, cognitive impairment, motor deterioration, hallucinations, and premature...
To investigate whether the phosphorylation of cyclic AMP response element-binding protein (CREB) is implicated in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the change in the level of CREB phosphorylation was analyzed in the spinal cord of Lewis rats with EAE. Western...
This study was performed to determine whether dexamethasone (DEX) had an effect on ATP-sensitive potassium channels ( K ATP channels) in blood–brain tumor barrier (BTB). Using a rat brain glioma model, we found that DEX could significantly increase the expression of K ATP channels protein at...
Amylin and CCK activate the area postrema (AP)/nucleus of the solitary tract (NTS) – lateral parabrachial nucleus (LPBN) – central amygdala (CeA) pathway. However, except for the brainstem structures the role of these nuclei for the anorectic effect of these peptides is not yet well...
The purpose of this study was to determine the role of prostaglandin E 2 (PGE 2 ) in modulating neuronal activity of the dorsolateral periaqueductal gray (dl-PAG) through excitatory and inhibitory synaptic inputs. First, whole cell voltage-clamp recording was performed to obtain excitatory and...
Neuronal interleukin-16 (NIL-16) is a multi-PDZ domain protein expressed in post-mitotic neurons of the hippocampus and cerebellum. NIL-16 contains four PDZ domains, two of which are located within the neuron-specific N-terminal region. In yeast two-hybrid systems, the N-terminus of NIL-16...
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapy for Parkinson's disease; however, the mechanism whereby DBS ameliorates the symptoms of Parkinson's disease remains an area of intense research. In the present study, we investigated the hypothesis that the...
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