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This study examined whether the potent cannabinoid HU210 ameliorates axonal injury through its indirect action to stimulate the secretion of corticosterone. We observed that HU210 dramatically reduced peroxynitrite-induced axonal injury in rats receiving adrenalectomy and corticosterone...
Rapid processing of sound location is critical for orienting attention. The present study investigated whether contextually sensitive early neural responses elicited by occasional changes in sound location could be measured. Using an oddball paradigm with stimuli consisting of brief noise bursts...
Veins play an important role in the control of venous return, cardiac output and cardiovascular homeostasis. However, the central nervous system sites and effector systems involved in modulating venous function remain to be fully elucidated. The hypothalamic paraventricular nucleus (PVN) is an...
Event-related potentials (ERPs) were recorded to investigate the neural mechanisms of attention to the same or different levels of two compound letters presented concurrently in the left and right visual fields, respectively. Relative to the condition when attention was allocated to the global...
Human subjects have been found to be able to cognitively prepare themselves to resist to a TMS-induced central perturbation by selectively modulating the corticospinal excitability (CS). The aim of this study was to investigate the on-line adaptability of this cognitive tuning of CS excitability...
Hyperbaric oxygen (HBO) has been shown to preserve the integrity of the blood–brain barrier after cerebral ischemia. However, the underlying molecular mechanisms are currently unknown. We examined the effect of HBO on postischemic expression of the basal laminar component laminin-5 and on...
Compounds which modulate AMPA receptor function through allosteric mechanisms were examined for their effect on the binding of the agonist ( 3 H)fluorowillardiine (FW). Benzamide-type positive modulators (ampakines™) under all experimental circumstances increased ( 3 H)FW binding to native...
The central nucleus of amygdala was examined to identify the ultrastructural distribution of neurotrophins responsible for the complex of neuronal signaling processes which regulate synaptic transmission and neuronal plasticity, and possibly underlie memory formation. We investigated at the...
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