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The reported increase in brain-derived neurotrophic factor (BDNF) mRNA expression after antidepressant treatment is a cornerstone of the BDNF hypothesis of antidepressant action. However, if this increase becomes manifest on the BDNF protein level is unknown. In the present study we performed...
Here we describe the nerves innervating the perineal skin together with their sensory fields in the adult female rat. Electrophysiological recording showed that the lumbosacral and L6–S1 trunks, in part by way of the sacral plexus, transmit sensory information from the perineal skin via four...
Herpes simplex virus (HSV)-derived vectors have been suggested for potential use in gene therapy for Parkinson's disease (PD). HSV naturally infects adult neuronal cells and possesses a large genome for the insertion of transgenes. In the present study, we have used two different HSV constructs...
It is well known that metabotropic glutamate receptors (mGluRs) have multiple actions on neuronal excitability mediated by G-protein-coupled receptors, although the exact mechanisms by which these actions occur are not understood. This study examines the effects of mGluRs agonists on...
In murine corticostriatal slice cultures, we studied the protective effects of the bioenergetic compound creatine on neuronal cell death induced by the mitochondrial toxin 3-nitropropionic acid (3-NP). 3-NP caused a dose-dependent neuronal degeneration accompanied by an increased lactate...
Voltage-gated ion channels are critical to excitation-secretion coupling in nerve terminals. We have identified two distinct populations of rat neurohypophysial (NHP) terminals distinguished by size, neuropeptide content and electrophysiological properties, including resting membrane potential,...
Study of effects of kindling on affect has been complicated by the fact that anxiogenic, anxiolytic or no effects may be observed following kindling of the amygdala. Factors affecting behavioral outcome include strain of rat, hemisphere kindled, amygdala nucleus kindled and location of the...
Glia maturation factor (GMF) is a unique brain protein localized in astrocytes and some neuronal populations. Studies with overexpression of GMF using adenovirus vector have uncovered its regulatory role in intracellular signal transduction and downstream induction of biologically active...
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