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Diabetes-related cognitive dysfunction has been recognized for many years in humans, but the pathogenesis of this condition is poorly understood. Evidence from animal studies suggests that altered function of the blood–brain barrier (BBB) could be a potential cause contributing to this disease....
The impulse activity of muscle spindles isolated from the cat tenuissimus muscle was investigated under varying concentrations of the L-type calcium channel blocker nifedipine. At a concentration of 25 μM nifedipine impulse activity was clearly diminished in both primary and secondary endings....
Intracellular recordings were obtained from rat presumed jaw-closing motoneurons in slice preparations to investigate the involvement of the serotonin 7 (5-HT 7 ) receptors in serotonergic inhibition of the postspike medium-duration afterhyperpolarization (mAHP) and enhancement of the...
Prolonged low frequency stimulation (1 Hz, 15 min) induced significant long-term depression (LTD) in hippocampal CA1 region and superficial, but not deep, layers of rat medial entorhinal cortex (EC) in vitro. In the presence of D-AP5, significant LTD was induced in EC superficial layers, but not...
The purpose of this study was to evaluate the effects of the retinal environment and retinoic acid (RA) pretreatment on the differentiation of transplanted adult rat hippocampus-derived neural stem cells (AHSCs). AHSCs were transplanted into embryonic (E18) or neonatal (P6) rat retinal explants...
Using a previously developed model of acute normobaric hypoxic hypoxia on chick embryos, here we studied at embryonic day 12 the in vitro effect of two positive allosteric modulators of GABA binding, the barbiturate sodium pentobarbital and the neurosteroid allopregnanolone. In both cases an...
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