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Combined serotonin (5-HT) 2A and dopamine (DA) D 2 blockade has been shown to contribute to the ability of atypical antipsychotic drugs (APDs) to increase DA release in rat medial prefrontal cortex (mPFC). We provide additional support for this hypothesis by examining the effect of the selective...
Nitrogen–oxygen breathing mixtures, for pressures higher than 0.5 MPa, decrease the release of dopamine in the rat striatum, due to the narcotic potency of nitrogen. In contrast, high pressures of helium–oxygen breathing mixtures of more than 1–2 MPa induce an increase of the striatal...
The expression of parkinsonian motor symptoms may be partly attributed to an increase in GABAergic neurotransmission from hyperactive GABA/enkephalinergic striatopallidal efferents. The present study measured pallidal GABA A and μ-opioid receptor binding in normal cats and cats symptomatic for...
High seizure susceptibility in El mice is associated with disinhibition in the dentate gyrus (DG) and paired-pulse facilitation in the CA3 area in hippocampal slices (Brain Res. 745 (1997) 165; Brain Res. 779 (1998) 324). A decrease in γ-aminobutyric acid (GABA)-mediated inhibition and an...
Voltage-gated potassium channels containing the K.v.3.2 subunit are expressed in specific neuronal populations such as thalamocortical neurons and fast spiking GABAergic interneurons of the neocortex and hippocampus. These K + -channels play a major role in the regulation of firing properties in...
While the distribution of substance P in the auditory system is well illustrated, the localization of its receptors has not yet been documented. The goal of our study was to characterize the distribution of the tachykinin receptors NK1-R, NK2-R and NK3-R in the brainstem auditory nuclei of the...
The medullary reticular formation (MRF) receives convergent inputs from multiple somatic and pelvic/visceral territories. The effects of chronic 30-day lateral hemisections at T8 on the responses of single MRF neurons to noxious mechanical stimulation of both hindpaws was examined in...
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