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The importance of apolipoproteins in the central nervous system became increasingly clear with the association in 1993 of the ϵ 4 allele of apolipoprotein E with familial and sporadic late-onset Alzheimer's disease. Apolipoprotein E is a ligand for several receptors, most of which are found to...
Possible inputs to the DMH were studied first using the fluorescent retrograde tracer Fluorogold, and identified cell groups were then injected with the anterograde tracer PHAL to examine the distribution of labeled axons in and around the DMH. From this work, we conclude that the majority of...
The neurotoxicity of low-level long-term exposure to lead has a special relevance in children. An extensive database has provided a direct link between low-level lead exposure and deficits in the neurobehavioral–cognitive performance evidenced in childhood through adolescence....
Evidence from aged and demented humans has stimulated research on the effects of age on the integrity of cortical cholinergic afferents in rodents. However, a comprehensive review of the available data does not consistently support the hypothesis that normal aging in rodents robustly affects the...
Ethanol exposure during development is teratogenic. The central nervous system (CNS) is particularly susceptible to ethanol toxicity. In fact, heavy gestational ethanol consumption is one of the leading known causes of mental retardation in the Western world. Ethanol exposure disrupts the...
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