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The Ca 2+ /Calmodulin-dependent protein kinase (CaMK) family is activated in response to elevation of intracellular Ca 2+ , and includes CaMK1 (as well as CaMK2 and CaMK4), which exists as different isoforms (α, β, γ and δ). CaMK1 is present in several cell types and may be involved in...
Estrogen has been suggested to influence skeletal homeostasis by both increasing the sensitivity of the feedback control system for skeletal rigidity and acting directly on bone surfaces. The objective of the present study was to explore the proposed interaction between the skeletal effects of...
Osteopontin (OPN) is a secreted protein abundant in mineralized tissue extracellular matrices and bodily fluids. Previously we have shown that mineralized debris at surgical wound sites in bone and teeth are coated by macrophage-derived OPN and phagocytosed. Here, we have performed...
Rheumatoid arthritis (RA) is a sexually dimorphic autoimmune disorder exhibiting a higher disease prevalence and severity among females. This study was carried out to understand the role of the major sex hormones viz., testosterone, estrogen and progesterone on the severity in arthritis. The...
Background Striking geographic variation in the incidence of osteoporotic fracture has been shown in national and international studies. The contributing risk factors for this variation are not fully understood.
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