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Parkinson’s disease is an increasingly common disease of elderly patients who present a particular anaesthetic challenge. This review explores the epidemiology, aetiology, pathogenesis, and pathophysiology of the condition, particularly the possible role of genetic factors. The clinical...
Background. Isoflurane (0.25%) in premixed nitrous oxide and oxygen, 50/50, v/v (IN 2 O), has been suggested for pain relief in labour. Possible phase separation of the mixture was studied during simulated administration. Methods. A sinusoidal pump set at stroke volume of 2 litres and a rate of...
Background. Interest in combining local and general anaesthesia has lead to studies investigating possible interactions. In a prospective, randomized, double‐blind study, we tested whether local anaesthetics administered i.m. potentiate the hypnotic effect of propofol. Methods. Sixty patients...
Background. Anandamide, an endogenous lipid, activates both cannabinoid (CB 1 ) and vanilloid (VR1) receptors, both of which are co‐expressed in rat dorsal root ganglion (DRG) cells. Activation of either receptor results in analgesia but the relative contribution of CB 1 and VR1 in...
Background. Mivacurium is a mixture of three isomers, two of which are rapidly broken down in vivo by plasma cholinesterases. This study investigates the stereospecificity of mivacurium in vitro degradation to determine if it accounts for its in vivo behaviour. Methods. The in vitro rate of...
Background. Recent evidence indicates that sevoflurane treatment before prolonged ischaemia reduces infarct size in normal hearts, mimicking ischaemic preconditioning. We examined whether exposure to sevoflurane before brief ischaemia, inducing a ‘stunned myocardium’, provided such protective...
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