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The discovery of the phenomenon of RNA interference (RNAi) and its existence in mammals quickly suggested a great potential for use in disease therapy. Rapid advances have been made in the development of RNAi‐based technologies and promising results have been obtained from studies on mammalian...
Development in mammals is a complex process requiring gene expression to be spatially and temporally well‐regulated. Factors modulate gene functioning by controlling transcription, translation, or mRNA degradation. microRNAs (miRNAs) are a group of small RNA molecules (∼22 nucleotides) that...
One of the most important advances in biology in recent years may be the discovery of RNAs that can regulate gene expression. As one kind of such functional noncoding RNAs, microRNAs (miRNAs) form a class of endogenous 19–23‐nucleotide RNAs that can have important regulatory roles in animals...
MicroRNAs (miRNAs) are a group of small noncoding RNAs that have been identified in a variety of organisms. These small, 18–22‐nucleotide (nt) RNAs are transcribed as parts of longer molecules called pri‐miRNAs, which are processed in the nucleus into hairpin RNAs of 70–100 nt, called...
Mature microRNAs (miRNAs) are single‐stranded RNA molecules of 17–24 nucleotides (nt) in length that are encoded in the genomes of plants and animals. The seminal discoveries of miRNA made in C. elegans have led the way to the rampant discoveries being made today in this field. Since each...
Mammals have evolved a variety of gene regulatory mechanisms to ensure the proper development of tissues during embryonic organogenesis. Recently, microRNAs (miRNAs) have been shown to regulate protein dosage during mammalian development. miRNAs are tiny RNA molecules that function to regulate...
MicroRNAs (miRNAs) are a group of recently discovered small RNAs produced by the cell using a unique process, involving RNA polymerase II, Microprocessor protein complex, and the RNAase III/Dicer endonuclease complex, and subsequently sequestered in an miRNA ribonucleoprotein complex. The...
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