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Sang Yup Lee awarded 2008 Merck Award for Metabolic EngineeringBiocat Award 2008 for biocatalysisMacArthur Award for German‐American plant evolution biologistRSC Sensors Award 2008 for ‘catch‐and‐tell’ molecules
The aim of this study was to investigate the role of concanavalin A (Con A)‐cellulose‐bound tomato peroxidase for the decolorization of direct dyes. Cellulose was used as an inexpensive material for the preparation of bioaffinity support. Con A‐cellulose‐bound tomato peroxidase exhibited...
The green microalgae Haematococcus pluvialis synthesizes secondary carotenoids after exposure to environmental stress, a process that is used for the biotechnological production of astaxanthin (Ax). This study reports, for the first time, the medium‐dependent changes in the carotenoid pattern...
Microbial feruloyl esterases acting on plant cell wall polymers represent key tools for the degradation of plant cell wall. In this paper, we describe in detail the microbial production, partial purification and characterization of feruloyl esterase from a culture medium of Aspergillus awamori...
A small‐volume chromatography system was developed for rapid resin and parameter screening and applied to the purification of a therapeutic monoclonal antibody from a key product‐related impurity. Accounting for constraints in peripheral volume, gradient formation, column integrity, and...
Many types of mammalian cells can aggregate and differentiate into 3‐D multicellular spheroids when cultured in suspension or a nonadhesive environment. Compared to conventional monolayer cultures, multicellular spheroids resemble real tissues better in terms of structural and functional...
Monoclonal antibodies represent a major and increasingly important category of biotechnology products for the treatment of human diseases. The state‐of‐the‐art of antibody technology has evolved to the point where therapeutic monoclonal antibodies, that are practically indistinguishable...
Phosphodiesterases (PDEs) hydrolyze cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and guanosine monophosphate (cGMP) into inactive 5' monophosphates, and exist as 11 families. Inhibitors of PDEs allow the elevation of cAMP and cGMP, which leads to a variety of cellular effects...
Cover illustration: Focus on Antibodies. This issue of Biotechnology Journal features relevant articles about antibody production, stability and humanization. Clearly, these developments contribute to make antibodies the most successful biopharmaceuticals, which are slowly but surely dominating...
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