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The last 50 years have seen an increasing emphasis on ethical, moral, social, legal, political and economic implications of science for reasons that are discussed in this article. Biotechnology has been no exception to this trend. Areas of biotechnology where the above implications have been...
The enantioselective bioreduction of acetophenone and its various analogues has been carried out using a new yeast strain, Candida tropicalis MTCC 5158, to obtain the corresponding (S)-aryl ethanols with good yield and almost absolute enantioselectivity. The catalytic ability of this microbial...
Prions are misfolded proteins capable of propagating their altered conformation which are commonly considered as the causative agent of transmissible spongiform encephalopathies, a class of fatal neurodegenerative diseases. Currently, no treatment for prion-based diseases is available. Recently...
Dicarboxylic acids (DCAs) can be obtained by oxidizing alkanes by Candida tropicalis. Through ॅ-monocarboxylic acids (MCAs), ॅ- and ३-oxidation yield ॅ- or ३-DCAs, respectively. However, both MCAs and DCAs may be degraded to acetyl-CoA by ॆ-oxidation, resulting in a limited DCA yield....
Recombinant immunosuppressants have come of age and represent a significant class of quite diverse drugs. They target extracellular molecules, and either label or inhibit them. Those targets are soluble factors or membrane proteins almost all of which are components of a very complex molecular...
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