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With an ageing population, the incidence of Parkinson's disease is increasing. The disease has an overwhelming impact on those it affects and has a limited repertoire of drug therapies available, each with problematic side effects. Stem cell therapy is an exciting prospect in the treatment of...
Adaptation to hypoxia is essential to survival in most organisms; disruption of oxygen homeostasis is linked to the pathology of multiple diseases including neurodegeneration, ischaemic stroke and cancer. Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of oxygen...
With a continuing increase in the prevalence of cancer, there is an increasing pressure to produce novel cancer therapies. The production of targeted cancer therapies could lead to the replacement of conventional cancer chemotherapy and, consequently, the minimization of the associated...
Neurodegenerative disorders such as Huntington's, Alzheimer's, Parkinson's and prion diseases are progressive and without a cure. A common finding is one of misfolded protein aggregates, conventionally believed to underlie pathogenesis via a toxic gain of function. Recently, a potential...
Reductions in cardiac infarct size can be achieved in ischaemic preconditioning, a procedure which subjects the heart to intermittent, non-lethal cycles of ischaemia and reperfusion. Similar cardioprotection can be induced upon preconditioning distal tissues such as the upper limb, and this...
Up-frameshift protein 1 (Upf1) is a multidomain RNA helicase that is conserved from yeast to humans. Upf1 is critical for nonsense-mediated decay (NMD), a quality control mechanism that detects and eliminates aberrant transcripts harbouring a premature termination codon (PTC) and thus plays an...
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